COLUMBUS, Ohio – New research strongly suggests that a mix of preventative agents, such as those found in concentrated black raspberries, may more effectively inhibit cancer development than single agents aimed at shutting down a particular gene.
Researchers at the Ohio State University Comprehensive Cancer Center examined the effect of freeze-dried black raspberries on genes altered by a chemical carcinogen in an animal model of esophageal cancer.
Garry D. Stoner
The carcinogen affected the activity of some 2,200 genes in the animals’ esophagus in only one week, but 460 of those genes were restored to normal activity in animals that consumed freeze-dried black raspberry powder as part of their diet during the exposure.
These findings, published in recent issue of the journal Cancer Research, also helped identify 53 genes that may play a fundamental role in early cancer development and may therefore be important targets for chemoprevention agents.
“We have clearly shown that berries, which contain a variety of anticancer compounds, have a genome-wide effect on the expression of genes involved in cancer development,” says principal investigator Gary D. Stoner, a professor of pathology, human nutrition and medicine who studies dietary agents for the prevention of esophageal cancer.
“This suggests to us that a mixture of preventative agents, which berries provide, may more effectively prevent cancer than a single agent that targets only one or a few genes.”
“Freeze drying the berries concentrates these elements about ten times, giving us a power pack of chemoprevention agents that can influence the different signaling pathways that are deregulated in cancer,” he says.
To conduct this study, Stoner and his colleagues fed rats either a normal diet or a diet containing 5 percent black-raspberry powder. During the third week, half the animals in each diet group were injected three times with a chemical carcinogen, N-nitrosomethylbenzylamine. The animals continued consuming the diets during the week of carcinogen treatment.
After the third week, the researchers examined the animals’ esophageal tissue, thereby capturing gene changes that occur early during carcinogen exposure. Their analyses included measuring the activity, or expression levels, of 41,000 genes. In the carcinogen-treated animals, 2,261 of these genes showed changes in activity of 50 percent or higher.
“These changes in gene expression correlated with changes in the tissue that included greater cell proliferation, marked inflammation, and increased apoptosis,” Stoner says.
In the animals fed berry powder, however, a fifth of the carcinogen affected genes – exactly 462 of them – showed near-normal levels of activity, when compared with controls. Most of these genes are associated with cell proliferation and death, cell attachment and movement, the growth of new blood vessels and other processes that contribute to cancer development. The tissue also appeared more normal and healthy.
Lastly, of the 462 genes restored to normal by the berries, 53 of them were also returned to normal by a second chemoprevention agent tested during a companion study.
“Because both berries and the second agent maintain near-normal levels of expression of these 53 genes, we believe their early deregulation may be especially important in the development of esophageal cancer,” Stoner says.
“What’s emerging from studies in cancer chemoprevention is that using single compounds alone is not enough,” Stoner says. “And berries are not enough. We never get 100 percent tumor inhibition with berries. So we need to think about another food that we can add to them that will boost the chemopreventive activities of berries alone.”
Funding from the National Cancer Institute supported this research.
ENT, Andrew Cheng, M.D., Offers Tips for Easing the Intensity of Tinnitus.
Edison, NJ August 27, 2008 -- Attend too many loud rock concerts back in the day? Are you asking yourself, "What is that ringing or buzzing in your ear?" Well, it could be tinnitus, or ringing in the ear, a disturbing condition that often occurs with presbycusis, a type of age-related hearing loss.
|For some, the noise (ringing in the ear) is distressing enough to seek medical help, yet many suffer in silence because they don't know where to turn or how to explain it to others (who do not hear this noise)|
"For some, the noise (ringing in the ear) is distressing enough to seek medical help, yet many suffer in silence because they don't know where to turn or how to explain it to others (who do not hear this noise)," explains Andrew Cheng, M.D., an ear, nose and throat physician and clinical assistant professor in the Department of Otolaryngology - Head & Neck Surgery at New York Medical College.
While there are some treatments available for tinnitus, or ringing in the ear, there is no real cure. Doctors suggest making lifestyle and dietary changes to help ease the intensity of the "ringing" (which can also appear as a whooshing or buzzing sound) including:
• Avoiding caffeine or alcohol
• Managing stress
• Avoiding exposure to additional loud noises which can aggravate tinnitus further (invest in a good pair of ear plugs)
• Taking Lipo-Flavonoid, a nutritional supplement that contains a complex of B vitamins proven to help decrease the intensity of tinnitus. Dr. Cheng sees improvement in seven out of 10 patients who take Lipo-Flavonoid, which is why he continues to recommend it to his tinnitus patients. The exact formulation of ingredients in Lipo-Flavonoid® has been clinically-tested to demonstrate relief
• Controlling blood pressure
• Decreasing salt/sodium intake
If you're still not hearing well or your ears feel odd after several days, Dr. Cheng recommends making an appointment with an ear, nose and throat doctor or your health care provider.
Innovations releases the Draganflyer X6 helicopter. This remotely
operated, unmanned, miniature helicopter is designed to carry wireless
video cameras and still cameras.
The ease with which this helicopter can be piloted is the most revolutionary feature of the Draganflyer X6
Saskatoon, Saskatchewan August 27, 2008 -- Today, Draganfly Innovations announced the launch of the Draganflyer X6 helicopter, a miniature aircraft for commercial/industrial aerial video and photography. The Draganflyer X6 helicopter is easy to fly, capable of operating autonomously, and has an appearance that is nothing like a conventional helicopter. The unique design utilizes six main horizontal rotor blades and allows the Draganflyer X6 helicopter to hover efficiently and maneuver rapidly using differential thrust.
Remotely controlled aircraft are available for many purposes, and most fall into a class somewhere between toys and the high quality models piloted by hobbyists. Beyond this class is a large gap approaching the point where full size aircraft must be used to achieve tasks such as commercial photography and industrial inspection. In the past this gap was filled by model aircraft with additional equipment grafted on, which required skilled and trained pilots to operate. Draganfly Innovations has created a better alternative; a purpose built self-stabilizing multiple rotor helicopter specifically designed for filming high definition video and photographing high-resolution aerial pictures.
The Draganflyer X6 is a fully functional miniature unmanned electric powered helicopter. Aimed at industrial and commercial use, it provides reconnaissance and inspection information using on-board wireless video and still cameras. The Draganflyer X6 helicopter is able to fly autonomously or can be flown manually by remote control. The Draganflyer X6 helicopter achieves its stability by using an on-board processor running more than ten thousand lines of code and receiving data from eleven on-board sensors (three gyros, three accelerometers, three magnetometers, one barometric pressure sensor, and one GPS receiver). It can be piloted by users with minimal or zero training. The Draganflyer X6 helicopter determines its own orientation and motion and moves where the operator instructs it, automatically handling the complex attitude and altitude adjustments that would ordinarily require a practiced pilot. "The ease with which this helicopter can be piloted is the most revolutionary feature of the Draganflyer X6" says company president, Zenon Dragan.
The Draganflyer X6 helicopter can be put into GPS hold mode where it will maintain its position without any user input. This means that after activating GPS hold, the pilot can set the handheld controller on the ground while the Draganflyer X6 helicopter flies itself. This mode will allow the user to focus on other tasks such as aerial photography from the Draganflyer X6 helicopter.
The Draganflyer X6 helicopter uses interchangeable cameras, covering different areas of use. A high definition video camera provides 1080p resolution. For dawn and dusk use, there is a low light (0.0001lux) video camera. For night use or search and rescue, the thermal FLIR (Forward Looking Infra-Red) camera provides heat vision. High-resolution photographs can be captured with the 10.1 mega-pixel digital still camera. When using any of the camera modules, a viewfinder video signal is streamed wirelessly back to the operator for real-time viewing on video glasses. The camera mount tilts by remote control, and the helicopter can pan side to side or in a circle.
The Draganflyer X6 helicopter uses six custom designed high efficiency carbon fiber rotors and direct drive brushless motors which result in a quiet and maintenance free helicopter. The Draganflyer X6 helicopter weighs 1kg and has a payload capacity of 500 grams.
Durability and safety have been incorporated into the design of the Draganflyer X6 helicopter. With dual motors on each of the three arms, even if an in-flight collision causes one of the motors or rotors to stop working, the Draganflyer X6 helicopter will still be able to keep flying using the remaining five motors. This ability to fly with a missing motor or rotor is not found in any other comparable helicopter. Other safety features include bright LED navigation lights for safe flying at a distance or in darkness, and automatic self-landing if the radio link controlling the helicopter is lost. An on-board flight recorder (black box) stores telemetry and flight data in a removable memory card, and can be used for post flight analysis.
The Draganflyer X6 helicopter is flown using a custom designed handheld controller with a 2.8" color OLED touchscreen that displays telemetry and flight data. The handheld controller also receives streaming video sent by the Draganflyer X6 helicopter and passes this to the video goggles, enabling the operator to view what the helicopter is seeing while also keeping an eye on the helicopter itself.
‘Snobootz’ Designed for Safer Winter Driving
IDER, Ala. (Business Wire EON/PRWEB ) August 26, 2008 -- A unique new, lightweight tire accessory designed to help provide safer driving conditions in winter weather coupled with easy installation compared to snow chains is being announced today by Navimetrix.
|The driver simply drapes the boot over the tire, drives forward a few feet, then latches the hook-and-loop fastener which holds the boot to the tire.|
Kurt Lammon, president of Navimetrix, said, "Snobootz (available at www.snobootz.com) are a great way to help ensure family safety during snow and ice winter driving conditions. The installation usually requires about a minute per tire. Snobootz offer an ideal solution for winter traction, especially for smaller cars that often have wheel clearances too tight to allow the use of tire chains." Snobootz come as a set of two to cover both tires on the drive axle.
“The installation of Snobootz is simple and straightforward,” said Lammon. “The driver simply drapes the boot over the tire, drives forward a few feet, then latches the hook-and-loop fastener which holds the boot to the tire.”
Independent third-party testing at Michigan Tech University’s Keweenaw Research Center (KRC) proved that Snobootz was about 20 percent faster than snow chains on ice from zero to 20 mph on a full-size SUV. On a 10 percent ice-covered grade, Snobootz allow a vehicle to climb, come to a complete stop on the slope, and then continue the climb again without sliding backwards.
In KRC installation tests, Snobootz proved to be 66 percent faster than tire chains. This means the driver will be less exposed to roadside hazards, and more likely to use them when necessary. Also, at one-third the weight of chains, Snobootz are easier to handle and store. Lammon said that although Snobootz are not designed for extended use on dry pavement, the tough rubber traction pads have been proven to last more than 200 miles, which exceeds the life expectancy of tire chains on dry pavement.
Snobootz are available at www.snobootz.com at a suggested list price of $250 per pair.
GameChanger Products is launching Audio Bone Headphones - a revolutionary new way to enjoy stereo quality music on an iPod or MP3 player without blocking the ears. Audio Bone utilizes Bone Conduction technology to deliver music through the listener's bones instead of the ears - so ambient sounds like traffic and conversations can still be heard. Audio Bone is designed for runners, cyclists, office workers and construction workers.
Alameda, CA (PRWEB) August 26, 2008 -- GameChanger Products announces the introduction of Audio Bone Headphones to North America. Audio Bone headphones are a revolutionary new way to enjoy stereo quality music on iPods and MP3 players while minimizing "attention distraction" and ear drum damage.
|Everyone likes to listen to music on their iPod, but there are some places where regular headphones or ear buds are just not very safe|
"Everyone likes to listen to music on their iPod, but there are some places where regular headphones or ear buds are just not very safe," said Larry Popelka, CEO of GameChanger. "With Audio Bone's Ear Free Listening™ you can enjoy your music wherever you want, but still hear other things going on around you."
Audio Bone headphones are a great option for runners, cyclists, office and construction workers and others who want to listen to music but need to hear things around them. Lightweight, comfortable and weighing only 1.3 ounces, Audio Bone headphones rest comfortably in front of the ears, making them great Sport Headphones. They are also completely waterproof - so you can even swim with them.
Popelka, who himself is a runner and cyclist, said he never felt comfortable wearing normal headphones or ear buds while exercising. "Many of my friends run with one ear bud in so they can try to hear things. But the listening experience is poor and they find it disorienting."
Audio Bone's revolutionary technology is supported by a number of university and scientific studies on Bone Conduction that indicate this form of listening is safer because it does not put stress on the ear drum. In fact, since Audio Bone headphones transmit sound waves directly to the inner ear, people who suffer from ear drum damage may find Audio Bone helps them enjoy a wider range of music than they've experienced in years.
Audio Bone headphones work with all standard iPods and MP3 players. With 4 patents pending, Audio Bone is the successful result of years of R&D effort by GameChanger's Japanese partner, Goldendance Co. Ltd., to deliver a full range of stereo sound via Bone Conduction.
Audio Bone headphones are available in a variety of stylish colors at www.audioboneheadphones.com. GameChanger is also looking for retail and internet partners to expand distribution.
About GameChanger Products: GameChanger Products, LLC of Alameda, CA is a new Consumer Products Innovation company founded in 2007 by Larry Popelka, former VP of New Ventures at the Clorox Company. GameChanger's team also includes former executives from Procter & Gamble, Orange-Glo International and Leo Burnett.
I don't know what's more disturbing... that someone made this video about an avenging unicorn spearing and eating people... or that there is a real game for sale so you can play it yourself.
Watch this amusing and disturbing video or hit skip to just buy the game... for your kids... so they can grow up... warped.
Oh, and click the reviews section after the video (or skip to get to the widget). Some Amazon buyers have a funny sense of humor!
Our feet are getting bigger and millions are suffering, according to podiatrists and a top London shoe retailer. Too many people are wearing shoes that don't fit - and overweight people can expect their feet to splay and stretch permanently.
London, UK August 24, 2008 -- It's not just UK waists that are getting bigger. Feet are getting larger too.
Doctors and podiatrists are seeing increasing numbers of people with serious foot problems - and some believe that obesity is to blame.
Dr. Oliver Zong, an American foot expert believes weight gain has laid the foundations for wider, larger feet.
He told HealthNewsDigest.com: "By placing more pressure on your feet as you stand or walk the joints and ligaments have to work harder to maintain foot structure - and the more pressure your feet have to accommodate the more your feet will splay or stretch out when you bear weight. Overtime your feet will stop 'bouncing back' and they will eventually just stay wider."
London-based shoe retailer Jesol Umeria, MD at Widefitshoes.co.uk, (www.widefitshoes.co.uk) has been specialising in helping people with wider feet for years - and now business is booming.
He says: "We see people's misery every day of the week - and it's not just those with weight problems. Our shop staff and our 24/7 Helpline are helping more and more customers who are in so much discomfort they just don't know what to do."
He adds: "So many people, especially women, fail to wear the right shoes. They will flog their feet to death in ill-fitting footwear because they wrongly believe they can't buy the right style and fashions at the right price in wider/larger foot sizes."
And growing numbers of UK brides too are really putting their foot in it when they walk down the aisle, according to Umeria.
"More and more brides are spending their big day in pain - on what should be the happiest day of their lives", he says.
"Wearing the wrong shoes can cause a host of problems including bunions, corns, hammer toes and even tumours.
The population at large is growing but most shoes are still made to fit a size that is increasingly no longer average."
young women fight poolside about the existence of God, rather than
whether Miller Lite tastes great or is less filling. The ad promotes
the newly released Beyond Reasonable Doubt: A Lawyer's Case for
Disbelief in God by Geoff Henley, which provides an attorney's
perspective in a debate often dominated by scientists and clergy.
Throughout the work, Henley charges that all religious myths are bad
alibis and hearsay and that faith and God's law cruelly violate
traditional principles of due process.
Too bad all atheist-theist debates aren't this entertaining
Dallas, TX August 24, 2008 -- In a new twist on an age old debate, two young nubile women in string bikinis fight poolside about the existence of God in a new video.
As Wagner plays, the camera seductively pans across their bodies as they fight in slow motion about whether God is great.
Reminiscent of the Miller Lite cat fight, Monty Python or the burlesque Benny Hill Show, the risque parody has gotten rave Internet reviews, but neither the Vatican nor any other religious leaders have commented yet.
"Too bad all atheist-theist debates aren't this entertaining," says one reviewer.
"Not just theology, this is how all debates should be," adds another.
The action features Killer Films star Heather Westwood as a sexy skeptic reading Beyond Reasonable Doubt: A Lawyer's Case for Disbelief in God, while hot stage actress Amanda Durbin flips through a tabloid magazine.
When Durbin's character comes to understand what her friend is reading, she shows the disgust of a sorority girl judging a cheap, ugly pair of shoes. As Wagner's Ride of the Valkyries increases in volume and tempo, tempers flare when the skeptic challenges her belief.
The fight then degenerates in name calling and scrapping with water, sun tan oil and a provocative slow motion plunge into to the pool as mock epic battle continues to the music.
Under two and a half minutes, the video more resembles a beer commercial than a dry a debate on CSPAN.
Beyond Reasonable Doubt author Geoff Henley said that is exactly the message he intends.
"My goal is to integrate skepticism into popular culture," the Dallas lawyer says. "When we watch commercial TV, read newspapers, attend weddings and sporting events or drive through our neighborhoods at Easter, religion all gets a free plug. But to find something about skepticism, you have to go look for it on the Internet or at a bookstore."
Henley employs the same sexual innuendo in a companion video that depicts himself and Westwood in the familiar setting of a couple leaving the home. While Westwood finishes getting ready, Henley the Bible's Song of Solomon hidden behind a Hustler Magazine.
Though she cannot see what is doing, she suspects he is up to no good and goes to confront him. We will not spoil the spicy ending for you.
Sex and religion are common themes for Henley. In the excerpt available online, the Dallas lawyer compares a passage in the Koran that depicts Allah commanding a feminine earth and heaven to come to him as a rock star summoning the Barbie twins from across a crowed bar.
Beyond Reasonable Doubt provides an attorney's perspective in a debate often dominated by scientists and clergy. Throughout the work, Henley charges that all religious myths are bad alibis and hearsay.
Faith, damnation and salvation, the lawyer urges, are wholly incompatible with fairness and due process.
Besides relying on well-settled common law principles, Henley, a former prosecutor and personal injury, provides a number of personal accounts from law practice.
Beyond Reasonable Doubt may be found online at geoffhenley.com, Xlibris.com, Barnes&Noble.com, Amazon.com and Borders.com.
Entry: NAIL POLISH, ALUMINIUM AND A PIZZA OVEN - A RECIPE TO END WORLD POVERTY
Nicole Kuepper, a 23 year old solar cell scientist, has been voted Australia's favourite scientist in the Australian Museum Eureka Prizes People's Choice Award.
Often likened to the "Oscar's of Australian Science", the Australian Museum Eureka Prizes reward outstanding achievements in Australian scientific research, leadership and innovation, communication and journalism and school science.
While all other Australian Museum Eureka Prize winners are chosen by specially selected judging panels, the Eureka Prizes People's Choice Award lets the Australian people choose who should win a "science Oscar". Almost 16,000 people from across Australia cast their vote and chose Nicole as the winner.
For Kuepper, a PhD student and lecturer at the School of Photovoltaic and Renewable Energy Engineering at the University of New South Wales, the Eureka Prizes People's Choice Award was her second Eureka prize. She also won the British Council Eureka Prize for Young Leaders in Environmental Issues and Climate Change.
Nicole was awarded both Prizes for her work in developing and patenting a revolutionary solar cell that can be manufactured at low temperatures using everyday items like a pizza oven, nail polish and an inkjet printer. Nicole hopes that her technology will mean cheap, clean and green energy for developing countries, providing electricity to 2 billion of the world's poorest people.
Nicole's work in developing sources of renewable energy captured the imagination of the Australian people. "Your research is simply stunning, and I wish you the very best. The world is in desperate Sydney, wrote "We think any development in solar PV technology is brilliant, and especially if it's done in here in Oz!. Well done."
The Eureka Prizes People's Choice Award has proved a great hit with school students, with 65% of all votes coming from classrooms. From Narrogin to Dunedoo, Bungaree to Cooktown, school kids across the country researched, debated and voted for their favourite scientist.
"The Eureka Prizes People's Choice Award gives students real-life role models in science," said Frank Howarth, Director of the Australian Museum. "I'm sure any parents would be delighted for their child to aspire to the heights that Nicole has reached at such a young age."
Nicole was one of six finalists in the Eureka Prizes People's Choice Award who were selected from the hundreds of entries in the Eureka Prizes for scientific research.
The Eureka Prizes People's Choice Award is supported by the Department of Innovation, Industry, Science and Research, ABC, Abbey's Bookshop and Microsoft.
32% of British females would starve for their fashion, and half of the female population are spending more on clothes and accessories each month than they are on food, according to a celebrity fashion website, prompting the new diet phrase "fashiorexia".
London, UK August 22, 2008 -- The British public have been gorging themselves on fashion, not food, this summer so far, with nearly half, 49%, of people admitting to spending more on looking good than eating, and 18% of people spending more than half their wages each month on clothes and accessories.
Despite the Credit Crunch and reports that the public are now spending less on non-essential items, 49% of fashion hungry shoppers are spending more on their appearance on a monthly basis than food, according to research of 4,315 female members of the general public by star style stealing website MyCelebrityFashion.co.uk .
|Fashion is clearly still a thriving industry, despite the economy. More people are searching for the best deals and bargains online rather than traipse the high streets, and clearly enjoying themselves whilst doing it!|
The study found that the majority of the public; 34%, spend between £100-150 per person on food per month. In contrast, the average outlay of those polled was 11% of their wages, or £173.36.
71% of 18-25 year old females spend £150+ per month on clothing and accessories, of which 16% spend more than half their wages on looking good.
The biggest surprise is in the 31 - 40 year old category, where 21% of women claimed to spend more than half of their wages on fashion, and 56% admit to spending more on fashion than eating.
Speaking about the results, celebrity fashion websiteMyCelebrityFashion.co.uk Head Fashionista, Jill Tovey said,
"Fashion is clearly still a thriving industry, despite the economy. More people are searching for the best deals and bargains online rather than traipse the high streets, and clearly enjoying themselves whilst doing it!"
"With regards to 'fashiorexia', I and MyCelebrityFashion would never advocate eating unhealthily for the sake of fashion, and believe in balance."
Upon learning that Republican presidential candidate John McCain can't remember how many homes he owns, a company specializing in lunar real estate has offered the Arizona senator some property even he can't forget.
San Jose, Calif. August 22, 2008 -- Upon learning that Republican presidential candidate John McCain can't remember how many homes he owns, a company specializing in lunar real estate has offered the Arizona senator some property even he can't forget.
Lunar International, a company that offers lunar land claims to the public in order to support future lunar exploration efforts, has reserved an acre of moon property for McCain in the famed Sea of Tranquility.
|Both properties are in the same lunar region, but they aren't right next door to each other|
"We're truly touched that Senator McCain is so underwhelmed by his current homes that he can't even remember how many of them he owns," said Jackson James, president and chief lunar officer of Lunar International. "A man of his stature deserves real estate that's truly memorable."
Thanks in part to the popularity of the Google Lunar X Prize and other private space-tourism endeavors, the dream that non-astronauts can travel to outer space someday appears to be imminently achievable. A handful of organizations, including Lunar International, believe that private ownership and development of land on the moon will be the next logical step.
Lunar International donates a portion of each sale to the Society for Lunar Exploration and Development, an organization attempting to establish a system that allows regular Earth-bound citizens to own moon property. Should the group achieve its goals, those who purchased land claims through Lunar International -- and those like Senator McCain who received it as a gift -- would enjoy full property rights to their slice of real estate on the moon.
James said the company has also reserved an acre of moon property in the Sea of Tranquility for Democratic presidental candidate Barack Obama as well.
"Both properties are in the same lunar region, but they aren't right next door to each other," said James. "We thought that might just be too awkward."